Sensitive protein alignments at tree-of-life scale using DIAMOND.

Benjamin Buchfink Klaus Reuter Hajk-Georg Drost

Published in: Nature methods (2021)

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.

Keyphrases

protein protein
amino acid
binding protein
electronic health record
gene expression
big data
small molecule
copy number
dna methylation
data analysis
artificial intelligence
genetic diversity