Pre-treatment with IL2 gene therapy alleviates Staphylococcus aureus arthritis in mice.

Berglind BergmannYing FeiPernilla JirholtZhicheng HuMaria BergquistAbukar AliCatharina LindholmOlov EkwallGuillaume ChurlaudDavid KlatzmannTao JinInger Gjertsson

Published in: BMC infectious diseases (2020)

Pre-treatment with IL2 gene therapy dampens detrimental immune responses but preserves appropriate host defense, which alleviates S. aureus septic arthritis in a mouse model.

Keyphrases

gene therapy
mouse model
staphylococcus aureus
immune response
rheumatoid arthritis
pseudomonas aeruginosa
replacement therapy
high fat diet induced
innate immune