Quantification of renal function following stereotactic body radiotherapy for pancreatic cancer: secondary dosimetric analysis of a prospective clinical trial.

Vivek VermaAbhijeet R BhirudKyle A DennistonNathan R BennionChi Lin

Published in: Radiation oncology (London, England) (2017)

In the first known analysis of renal function after pancreatic SBRT, evaluating patients on a prospective study, V5 ≥ 210 cm3 was associated with a post-SBRT GFR decline of >23 mL/min/1.73 cm2. If V5 is kept <210 cm3, median GFR decline was only 11.8 mL/min/1.73 cm2. Further validation is needed to ascertain definite dose-volume parameters and examine late renal decline.

Keyphrases

radiation therapy
clinical trial
end stage renal disease
ejection fraction
newly diagnosed
early stage
peritoneal dialysis
locally advanced
patient reported outcomes
open label
patient reported
double blind