Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation.

Qin WangMichael V HolmesGeorge Davey SmithMika Ala-Korpela

Published in: Diabetes care (2017)

We provide robust evidence that IR causally affects each individual BCAA and inflammation. Taken together with existing studies, this implies that BCAA metabolism lies on a causal pathway from adiposity and IR to type 2 diabetes.

Keyphrases

insulin resistance
type diabetes
oxidative stress
adipose tissue
amino acid
high fat diet
metabolic syndrome
skeletal muscle
glycemic control
polycystic ovary syndrome
high fat diet induced
cardiovascular disease
genome wide
gene expression
weight gain