Enantiomer-Specific Cardiovascular Effects of the Ketone Body 3-Hydroxybutyrate.

Nigopan Gopalasingam Niels MoeslundKristian Hylleberg ChristensenKristoffer Berg Hansen Jacob Marthinsen Seefeldt Casper Homilius Erik Nguyen Nielsen Mie Ringgaard Dollerup Aage Kristian Olsen Alstrup Mogens Johannsen Donna M B Boedtkjer Niels Møller Hans Eiskjær Lars Christian Gormsen Bent Roni Ranghøj Nielsen Henrik Wiggers

Published in: Journal of the American Heart Association (2024)

3-OHB increased CO by reducing afterload. L-3-OHB exerted a stronger hemodynamic response than D-3-OHB due to higher circulating 3-OHB levels. There was a dissocitation between the myocardial metabolism and hemodynamic effects of the enantiomers, highlighting L-3-OHB as a potent cardiovascular agent with strong hemodynamic effects.

Keyphrases

left ventricular

heart failure

mass spectrometry

capillary electrophoresis