Tuberculosis and COVID-19 Dually Affect Human Th17 Cell Immune Response.
Anna A StarshinovaIgor KudryavtsevArtem A RubinshteinAnna MalkovaIrina DovgalukDmitry Anatolievich KudlayPublished in: Biomedicines (2023)
According to the data obtained, the course of tuberculosis proceeds in a dissimilar way due to the distinct immune response, elicited by SARS-CoV-2. Importantly, the development of active tuberculosis with a severe course is associated with a decline in Treg levels. Both pathogens lead to disturbed immune responses, increasing the risk of developing severe TB. The insights and findings of this paper may be used to improve the future management of individuals with latent and active tuberculosis.
Keyphrases
- immune response
- mycobacterium tuberculosis
- sars cov
- pulmonary tuberculosis
- hiv aids
- coronavirus disease
- dendritic cells
- toll like receptor
- endothelial cells
- respiratory syndrome coronavirus
- adverse drug
- single cell
- electronic health record
- mesenchymal stem cells
- bone marrow
- gram negative
- multidrug resistant
- antimicrobial resistance