Photoinduced Trifluoromethylation with CF 3 Br as a Trifluoromethyl Source: Synthesis of α-CF 3 -Substituted Ketones.

An efficient and novel photoinduced trifluoromethylation employing CF 3 Br as a trifluoromethyl source is described. With commercially accessible fac -Ir (III) (ppy) 3 as the catalyst, radical trifluoromethylation between O -silyl enol ether and CF 3 Br occurs successfully. This method provides various α-CF 3 -substituted ketones with a broad substrate scope in good yields under mild reaction conditions.