Role of nucleotide binding oligomerization domain-like receptor protein 3 inflammasome in stress-induced gastric injury.

Akira HigashimoriToshio WatanabeYuji NadataniAkinobu NakataKoji Otani Shuhei HosomiFumio TanakaNoriko KamataKoichi TairaYasuaki NagamiTetsuya TanigawaYasuhiro Fujiwara

Published in: Journal of gastroenterology and hepatology (2020)

These results suggest that NLRP3 inflammasome-derived IL-1β plays a protective role in stress-induced gastric injury via activation of the COX-2/PGE2 axis. Toll-like receptor 4 signaling and gastric acid may be involved in NLRP3 inflammasome activation.

Keyphrases

stress induced
nlrp inflammasome
toll like receptor
inflammatory response
nuclear factor
immune response
binding protein
small molecule