Icos gene disruption in NOD mice elicits myositis associated with anti-troponin T3 autoantibodies.

Gwladys BourdenetBaptiste PileyreLaurent DrouotJérémie MartinetChantal BécourtMarion CarretteGaétan RiouCécile BerguaThara JaworskiPhilippe ChanLaetitia JeanManuel FréretPascal CosetteChristian BoitardCatalina AbadOlivier Boyer

Published in: Neuropathology and applied neurobiology (2023)

NOD mice represent a spontaneous model of myositis and the discovery of anti-TNNT3 aAb suggests a new autoantigen in this model.

Keyphrases

high fat diet induced
interstitial lung disease
small molecule
systemic lupus erythematosus
high throughput
innate immune
insulin resistance
wild type
adipose tissue