Inflammation-sensing catalase-mimicking nanozymes alleviate acute kidney injury via reversing local oxidative stress.
Hong Sang ChoiAnsuja Pulickal MathewSaji UthamanArathy VasukuttyIn Jin KimSang Heon SuhChang Seong KimSeong Kwon MaSontyana Adonijah GrahamSoo Wan KimIn-Kyu ParkEun-Hui BaePublished in: Journal of nanobiotechnology (2022)
The findings of our study demonstrated the successful attenuation of inflammation and apoptosis in the IRI mice kidneys, suggesting that PTC-M nanozyme could possess promising potential in AKI therapy. This study paves the way for high-performance ROS depletion in treating various inflammation-related diseases.