Cardiac function, haemodynamics, and valve competence with exercise in patients with heart failure with preserved ejection fraction and mild to moderate secondary mitral regurgitation.
Tomonari HaradaJwan A NaserAtsushi TadaShunichi DoiTatsuro IbeSorin V PislaruMackram F EleidHidemi SorimachiMasaru ObokataYogesh N V ReddyBarry A BorlaugPublished in: European journal of heart failure (2024)
Patients with HFpEF and mild or moderate MR have more severe LV systolic dysfunction, LA myopathy, RV-PA uncoupling, and more severe pulmonary vascular disease. Mitral valve incompetence in this setting is a phenotypic marker of more advanced disease but is not a causal factor in development of HFpEF.
Keyphrases
- mitral valve
- left ventricular
- high intensity
- early onset
- blood pressure
- heart failure
- left atrial
- pulmonary hypertension
- aortic valve
- physical activity
- late onset
- magnetic resonance imaging
- nitric oxide
- coronary artery disease
- drug induced
- aortic stenosis
- transcatheter aortic valve replacement
- nitric oxide synthase
- myasthenia gravis