Total and subgenomic RNA viral load in patients infected with SARS-CoV-2 Alpha, Delta, and Omicron variants.
Derek E DimcheffChristopher N BlairYuwei ZhuJames D ChappellManjusha GaglaniTresa McNealShekhar A GhamandeJay S SteingrubNathan I ShapiroAbhijit DuggalLaurence W BusseAnne E P FroschIthan D PeltanDavid N HagerMichelle N GongMatthew C ExlineAkram KhanJennifer G WilsonNida QadirAdit A GindeDavid J DouinNicholas M MohrChristopher MallowEmily T MartinNicholas J JohnsonJonathan D CaseyWilliam B StubblefieldKevin W GibbsJennie H KwonH Keipp TalbotNatasha HalasaCarlos G GrijalvaAdrienne BaughmanKelsey N WomackKimberly W HartSydney A SwanDiya SurieNatalie J ThornburgMeredith L McMorrowWesley H SelfAdam S Lauringnull nullPublished in: The Journal of infectious diseases (2023)
RNA viral loads were similar among hospitalized adults, irrespective of infecting variant and known risk factors for severe COVID-19. Total N and subgenomic RNA N viral loads were highly correlated, suggesting that subgenomic RNA measurements adds little information for the purposes of estimating infectivity.