The inflammation-resolution promoting molecule resolvin-D1 prevents atrial proarrhythmic remodelling in experimental right heart disease.

Roddy HiramFeng XiongPatrice NaudJiening XiaoMartin SiroisJean-François TanguayJean Claude Tardif Stanley Nattel

Published in: Cardiovascular research (2022)

The inflammation-resolution enhancing molecule RvD1 prevents AF-promoting RA remodelling, while suppressing inflammatory changes and fibrotic/electrical remodelling, in RHD. Resolvins show potential promise in combating atrial arrhythmogenic remodelling by suppressing ongoing inflammatory signalling.

Keyphrases

oxidative stress
atrial fibrillation
rheumatoid arthritis
left atrial
single molecule
signaling pathway
mouse model
systemic sclerosis
pulmonary hypertension
heart failure
catheter ablation
idiopathic pulmonary fibrosis
left ventricular
interstitial lung disease