Alisol B 23-acetate attenuates CKD progression by regulating the renin-angiotensin system and gut-kidney axis.
Hua ChenMin-Chang WangYuan-Yuan ChenLin ChenYan-Ni WangNosratola D VaziriHua MiaoYing-Yong ZhaoPublished in: Therapeutic advances in chronic disease (2020)
These data suggest that ABA attenuated renal fibrosis through a mechanism associated with re-establishing dysbiosis of the gut microbiome and regulating blood pressure, and Smad7-mediated inhibition of Smad3 phosphorylation. Thus, we demonstrate ABA as a promising candidate for treatment of CKD by improving the gut microbiome and regulating blood pressure.
Keyphrases
- blood pressure
- chronic kidney disease
- epithelial mesenchymal transition
- transforming growth factor
- transcription factor
- hypertensive patients
- heart rate
- arabidopsis thaliana
- electronic health record
- big data
- blood glucose
- machine learning
- signaling pathway
- combination therapy
- liver fibrosis
- weight loss
- replacement therapy