A Pharmacokinetics-Informed Approach to Navigating Hydroxychloroquine Shortages in Patients With Rheumatic Disease During the COVID-19 Pandemic.
Marc H ScheetzMaximilian Ferdinand KonigPhilip C RobinsonJeffrey A SparksAlfred Hyoungju KimPublished in: ACR open rheumatology (2020)
Although mean blood concentrations exceed 700 ng/ml for a longer time if patients maintain their full dose of HCQ, more information is needed to fully understand the elimination of HCQ at the patient level, particularly the contribution of tissue stores of HCQ transiting back into the blood.