Alpha-Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction.

Giulia PonterioGaia FaustiniIlham El AtiallahGiuseppe SciamannaMaria MeringoloAnnalisa TassonePaola ImbrianiSilvia CerriGiuseppina MartellaPaola BonsiArianna Bellucci Antonio Pisani

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

Our data demonstrate an unprecedented relationship between TA and α-Syn, and reveal that α-Syn and SNAREs alterations characterize the synaptic dysfunction underlying DYT1 dystonia. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson Movement Disorder Society.

Keyphrases

deep brain stimulation
early onset
parkinson disease
oxidative stress
prefrontal cortex
electronic health record
genome wide
functional connectivity
big data
single cell