Assessment and predictive ability of the absolute neutrophil count in peripheral blood for in vivo CAR T cells expansion and CRS.

Man ZhangXiaolu LongYi XiaoJin JinCaixia ChenJiao MengWanying LiuAichun LiuLiting Chen

Published in: Journal for immunotherapy of cancer (2023)

Thus, we suggest ANC as an evaluative and predictive biomarker for CAR expansion and CRS during CAR T cell therapy, which can help to maximize clinical efficacy, reduce treatment-related toxicity and prolong survival.

Keyphrases

cell therapy
peripheral blood
induced apoptosis
stem cells
mesenchymal stem cells
cell cycle arrest
oxidative stress
cell death
endoplasmic reticulum stress
bone marrow