Subjective cognitive complaints at age 70: associations with amyloid and mental health.
Ivanna M PavisicKirsty LuSarah E KeussSarah-Naomi JamesChristopher A LaneThomas D ParkerAshvini KeshavanSarah M BuchananHeidi Murray-SmithDavid M CashWilliam CoathAndrew WongNick C FoxSebastian J CrutchMarcus RichardsJonathan M SchottPublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
This cross-sectional study demonstrates that symptoms of SCD are associated with both β-amyloid pathology, and more consistently, trait anxiety in a population-based cohort of older adults, at an age when those who are destined to develop dementia are still likely to be some years away from symptoms. This highlights the necessity of considering anxiety symptoms when assessing Alzheimer's disease pathology and SCD.