Piezo1-induced durotaxis of pancreatic stellate cells depends on TRPC1 and TRPV4 channels.
Ilka BuddeAndré SchlichtingDavid IngSandra SchimmelpfennigAnna KuntzeBenedikt FelsJoelle M-J RomacSandip M SwainRodger A LiddleAngela StevensAlbrecht SchwabZoltan PethöPublished in: bioRxiv : the preprint server for biology (2024)
Cells move towards regions with higher stiffness in a process called durotaxis. This study shows that ion channels Piezo1, TRPV4, and TRPC1 are crucial sensors in pancreatic stellate cells. They act together to orchestrate durotaxis of pancreatic stellate cells which may be relevant in pancreatic cancer.