Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis.
Xiaohua HuangZhongshi HuangZhongheng WeiYun FengXuebin LiLiangxue LaiChongdong JianPublished in: BioMed research international (2022)
Endothelial cells are heterogeneous, stemming from multiple organs, but there is still little known about the connection between the brain and kidney endothelial cells, especially in homeostasis. In this study, scRNA-seq results were obtained to compare genetic profiles and biological features of tissue-specific endothelial cells. On this basis, seven endothelial cell subpopulations were identified, two of which were upregulated genes in pathways related to stroke and/or depression, as characterized by neuroinflammation. This study revealed the similarities and distinctions between brain and kidney endothelial cells, providing baseline information needed to fully understand the relationship between renal diseases and neuroinflammation, such as stroke and depression.
Keyphrases
- endothelial cells
- high glucose
- cerebral ischemia
- genome wide
- vascular endothelial growth factor
- resting state
- single cell
- atrial fibrillation
- white matter
- depressive symptoms
- traumatic brain injury
- rna seq
- gene expression
- lipopolysaccharide induced
- multiple sclerosis
- functional connectivity
- lps induced
- subarachnoid hemorrhage
- healthcare
- copy number