BRAF mutation is not associated with an increased risk of recurrence in patients undergoing resection of colorectal liver metastases.
J-B BachetN Moreno-LopezL ViganoU MarcheseM GelliL RaouxS TruantC LaurentAstrid HerreroBertrand Le RoyS Deguelte LardiereGuillaume PassotV HautefeuilleC De La FouchardiereP ArtruT AmetoJ Y MabrutL SchwarzB RousseauC LepèreR CoriatA BrouquetA Sa CunhaStéphane BenoistPublished in: The British journal of surgery (2019)
These results support surgical treatment for resectable BRAF-mutated CRLM, as BRAF mutation by itself does not increase the risk of relapse after resection. BRAF mutation is associated with worse survival in patients whose disease relapses after resection of CRLM, as for non-metastatic colorectal cancer.