Putative mobilized colistin resistance genes in the human gut microbiome.
Bruno G N AndradeTobias GorisHaithem AfliFelipe H CoutinhoAlberto M R DávilaRafael R C CuadratPublished in: BMC microbiology (2021)
This study uncovers the diversity of mcr-like genes in the human gut microbiome. We demonstrated the cosmopolitan distribution of these genes in individuals worldwide and the co-presence of other antibiotic resistance genes, including Extended-spectrum Beta-Lactamases (ESBL). Also, we described mcr-like genes fused to a PAP2-like domain in S. wadsworthensis. These novel sequences increase our knowledge about the diversity and evolution of mcr-like genes. Future research should focus on activity, genetic mobility and a potential colistin resistance in the corresponding strains to experimentally validate those findings.
Keyphrases
- escherichia coli
- genome wide
- klebsiella pneumoniae
- multidrug resistant
- genome wide identification
- bioinformatics analysis
- endothelial cells
- antibiotic resistance genes
- healthcare
- pseudomonas aeruginosa
- acinetobacter baumannii
- drug resistant
- microbial community
- wastewater treatment
- dna methylation
- gene expression
- gram negative
- copy number
- transcription factor
- climate change
- human health