Identification and validation of methylated PENK gene for early detection of bladder cancer using urine DNA.

Tae Jeong OhEunkyung LimBo-Ram BangJustin Junguek LeeYong Gil NaJu Hyun ShinJae Sung LimKi Hak SongSungwhan An

Published in: BMC cancer (2022)

In this study, we analyzed the comprehensive patterns of DNA methylation identified that PENK methylation possesses a high potential as a biomarker for urine-based early detection of BCa. Validation of PENK methylation confirms that it could significantly improve the noninvasive detection of BCa.

Keyphrases

dna methylation
genome wide
copy number
gene expression
circulating tumor
single molecule
cell free
loop mediated isothermal amplification
risk assessment
human health
real time pcr
bioinformatics analysis
genome wide identification
nucleic acid
sensitive detection