Modulation of the Tryptophan Hydroxylase 1/Monoamine Oxidase-A/5-Hydroxytryptamine/5-Hydroxytryptamine Receptor 2A/2B/2C Axis Regulates Biliary Proliferation and Liver Fibrosis During Cholestasis.
Konstantina KyritsiLixian ChenApril O'BrienHeather FrancisTravis W HeinJulie VenterNan WuLudovica CeciTianhao ZhouDavid ZawiejaAnatoliy A GashevFanyin MengInvernizzi PietroLuca FabrisChaodong WuNicholas J SkillRomil SaxenaSuthat LiangpunsakulGianfranco AlpiniShannon S GlaserPublished in: Hepatology (Baltimore, Md.) (2019)
Modulation of the TPH1/MAO-A/5HT/5HTR2A/2B/2C axis may represent a therapeutic approach for management of cholangiopathies, including PSC.