Preoperative Treatment of Locally Advanced Rectal Cancer.
Deborah SchragQian ShiMartin R WeiserMarc J GollubLeonard B SaltzBenjamin L MusherJoel GoldbergTareq Al BaghdadiKaryn A GoodmanRobert R McWilliamsJeffrey M FarmaThomas J GeorgeHagen F KenneckeArdaman ShergillMichael MontemurroGarth D NelsonBrian ColgroveVallerie GordonAlan P VenookEileen M O'ReillyJeffrey A MeyerhardtAmylou C DueckEthan M BaschGeorge J ChangHarvey J MamonPublished in: The New England journal of medicine (2023)
In patients with locally advanced rectal cancer who were eligible for sphincter-sparing surgery, preoperative FOLFOX was noninferior to preoperative chemoradiotherapy with respect to disease-free survival. (Funded by the National Cancer Institute; PROSPECT ClinicalTrials.gov number, NCT01515787.).