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Myeloid-Derived Suppressor Cells Recruited by Chemokine (C-C Motif) Ligand 3 Promote the Progression of Breast Cancer via Phosphoinositide 3-Kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling.

Anqi LuoMin MengGuanying WangRui HanYujiao ZhangXin JingLin ZhaoShanzhi GuXinhan Zhao
Published in: Journal of breast cancer (2020)
CCL3 promoted the growth of breast cancer cells, and MDSCs recruited by CCL3 interacted with these cells and then activated the PI3K-Akt-mTOR pathway, which led to EMT and promoted the migration and invasion of the cells.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • protein kinase
  • breast cancer cells
  • endoplasmic reticulum stress
  • young adults
  • cell proliferation
  • pi k akt
  • breast cancer risk