Autonomic, Endocrine, and Inflammation Profiles in Functional Neurological Disorder: A Systematic Review and Meta-Analysis.

Sara Paredes-EcheverriJulie MaggioIndrit BègueSusannah PickTimothy R NicholsonDavid L Perez

Published in: The Journal of neuropsychiatry and clinical neurosciences (2021)

Inflammation research in FND remains in its early stages. Moving forward, there is a need for the use of larger sample sizes to consider the complex interplay between functional neurological symptoms and behavioral, psychological, autonomic, endocrine, inflammation, neuroimaging, and epigenetic/genetic data. More research is also needed to determine whether FND is mechanistically (and etiologically) similar or distinct across phenotypes.

Keyphrases

oxidative stress
heart rate variability
heart rate
gene expression
electronic health record
machine learning
big data
sleep quality
cerebral ischemia
brain injury
deep learning
blood brain barrier