Spontaneous splenic rupture from indeterminate dendritic cell proliferation: a case report.
Shaikh B IqbalAbhinandan R ChittalShiavax J RaoPallavi LakraDeepty BhansaliGeorge PyrgosPublished in: Journal of surgical case reports (2022)
Spontaneous splenic rupture is a rare and life-threatening phenomenon, usually associated with an underlying infectious, inflammatory, hematological, neoplastic or rheumatologic condition. Indeterminate cell tumor is a rare neoplastic dendritic cell disorder that is poorly understood but shares immunophenotypic markers for Langerhans cells without Birbeck granules. A 73-year-old man presented with upper abdominal pain after an unwitnessed fall. Computed tomography angiography showed splenomegaly and a large ruptured splenic subcapsular hematoma. Intraoperative findings from an emergency laparotomy revealed a large hemoperitoneum and a ruptured spleen. Microscopic sections identified numerous, mostly poorly formed, small nodules classified as a proliferation of indeterminate dendritic cell tumors.
Keyphrases
- dendritic cells
- abdominal pain
- cell proliferation
- single cell
- regulatory t cells
- induced apoptosis
- fine needle aspiration
- abdominal aortic aneurysm
- immune response
- subarachnoid hemorrhage
- cell cycle arrest
- signaling pathway
- public health
- emergency department
- coronary artery
- oxidative stress
- endovascular treatment
- patients undergoing
- pi k akt
- magnetic resonance imaging
- stem cells
- magnetic resonance
- brain injury
- computed tomography
- bone marrow
- emergency medical