Breast Cancer Stem Cells Secrete MIF to Mediate Tumor Metabolic Reprogramming That Drives Immune Evasion.

Linlin Yan Mingming Wu Tianyu Wang Hui Yuan Xiao Zhang Huafeng Zhang Tao Li Vijay Pandey Xinghua Han Peter E Lobie Tao Zhu

Published in: Cancer research (2024)

MIF secreted by breast cancer stem cells induces metabolic reprogramming in bulk tumor cells and engenders an immunosuppressive microenvironment, identifying MIF targeting as a strategy to improve immunotherapy efficacy in breast cancer.

Keyphrases

stem cells
cancer stem cells
cancer therapy
cell therapy
young adults
mesenchymal stem cells
drug delivery