Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM-1 in rats.

Klaudia M MaksymiukMateusz SzudzikMarta Gawryś-KopczyńskaMaksymilian OnyszkiewiczEmilia SamborowskaIzabella MogilnickaMarcin Ufnal

Published in: Journal of translational medicine (2022)

Chronic exposure to TMA increases blood pressure and increases markers of kidney damage, including proteinuria and KIM-1. TMA is rapidly oxidized to TMAO in rats, which may limit the toxic effects of TMA on other organs.

Keyphrases

blood pressure
hypertensive patients
oxidative stress
heart rate
type diabetes
metabolic syndrome
blood glucose
drug induced