Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema.
Sanja BlaskovicYves DonatiIsabelle Ruchonnet-MetraillerYannick AvilaDominik SchittnyChristian Matthias SchlepützJohannes Constantin SchittnyConstance Barazzone-ArgiroffoPublished in: Respiratory research (2022)
Our study reports a broad spectrum of transient transcriptomic changes in mouse emphysema and identifies nicotine as influencing the emphysema-associated immune system response.
Keyphrases
- early life
- chronic obstructive pulmonary disease
- lung function
- pulmonary fibrosis
- genome wide
- smoking cessation
- idiopathic pulmonary fibrosis
- high glucose
- single cell
- emergency department
- copy number
- cystic fibrosis
- gene expression
- air pollution
- rna seq
- drug induced
- cerebral ischemia
- endothelial cells
- subarachnoid hemorrhage
- adverse drug