Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study.

Xinyu GuoWenyan JinYuchen WenZhiqin WangXiaotong RenZhaoyun LiuRong FuZhigang CaiLijuan Li

Published in: Journal of translational medicine (2024)

Through scRNA-seq analysis on unsorted cells from BM aspiration samples of MDS patients, this study systematically profiled the development abnormalities in hematopoiesis, heterogeneity of risk, and T-cell microenvironment at the single cell level.

Keyphrases

single cell
rna seq
end stage renal disease
high throughput
ejection fraction
chronic kidney disease
newly diagnosed
gene expression
prognostic factors
data analysis