MEK1/2- and ERK1/2-Mediated Lung Endothelial Injury and Altered Hemostasis Promote Diffuse Alveolar Hemorrhage in Murine Lupus.

Haoyang Zhuang Shuhong HanNeil S HarrisWestley H Reeves

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Pristane treatment promotes lung endothelial injury and DAH in B6 mice by activating the MEK1/2-ERK1/2 pathway and impairing hemostasis. The hereditary factors determining susceptibility to lung injury and bleeding in pristane-induced lupus are relevant to the pathophysiology of life-threatening DAH in systemic lupus erythematosus and may help to optimize therapy.

Keyphrases

pi k akt
signaling pathway
systemic lupus erythematosus
endothelial cells
disease activity
high glucose
cell proliferation
atrial fibrillation
low grade
stem cells
type diabetes
high fat diet induced
oxidative stress
adipose tissue
insulin resistance
high grade
combination therapy
skeletal muscle
smoking cessation