Proton magnetic resonance spectroscopy detects cerebral metabolic derangement in a mouse model of brain coenzyme a deficiency.

Yanan LiJeffrey SteinbergZane ColemanShubo WangChitra SubramanianYimei LiZoltan PatayWalter AkersCharles O RockSuzanne JackowskiPuneet Bagga

Published in: Journal of translational medicine (2022)

BBP-671 treatment completely restored glutamate/glutamine levels in the brains of the mouse model, suggesting that these metabolites are promising clinically translatable biomarkers for future therapeutic trials.

Keyphrases

mouse model
ms ms
white matter
replacement therapy
current status
multiple sclerosis