Dual orexin/hypocretin receptor antagonism attenuates attentional impairments in an NMDA receptor hypofunction model of schizophrenia.

Eden B ManessSarah A BlumenthalJoshua A Burk

Published in: bioRxiv : the preprint server for biology (2023)

Schizophrenia is associated with attentional deficits that may stem from abnormally reactive BF projections to the prefrontal cortexOrexin receptor antagonists decrease acetylcholine release and reduce prefrontal cortical activityThe dual orexin receptor antagonist filorexant alleviated impairments of attention following NMDA receptor blockade.

Keyphrases

working memory
bipolar disorder
traumatic brain injury
transcranial magnetic stimulation
functional connectivity
binding protein