Non-lesional white matter in relapsing-remitting multiple sclerosis assessed by multicomponent T2 relaxation.
Pietro BontempiUmberto RozzanigoSabrina MarangoniElena FogazziDaniele RavanelliLucia CazzolettiBruno GiomettoPaolo FaracePublished in: Brain and behavior (2023)
T2 relaxation allowed identifying subtle WM alterations, which significantly correlated with EDSS, disease duration, and age but do not seem to be EDSS-predictors independent from FL sub-volumes in stable RR patients. Particularly, the increase in the Fw component is suggestive of an uninvestigated prodromal phenomenon in brain degeneration.
Keyphrases
- multiple sclerosis
- white matter
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- single molecule
- prognostic factors
- disease activity
- parkinson disease
- rheumatoid arthritis
- patient reported outcomes
- resting state
- deep brain stimulation
- subarachnoid hemorrhage
- patient reported
- functional connectivity
- cerebral ischemia