Exploring the Molecular Mechanism by which Kaempferol Attenuates Sepsis-related Acute Respiratory Distress Syndrome Based on Network Pharmacology and Experimental Verification.
Weichao DingChangbao HuangJuan ChenWei ZhangMengmeng WangXiaohang JiShinan NieZhaorui SunPublished in: Current computer-aided drug design (2024)
Kaempferol can reduce inflammatory response, ROS production, and cell apoptosis by acting on the HIF-1, NF-κB, and PI3K-Akt signaling pathways, thereby alleviating sepsis- related ARDS.
Keyphrases
- pi k akt
- acute respiratory distress syndrome
- signaling pathway
- extracorporeal membrane oxygenation
- cell proliferation
- inflammatory response
- mechanical ventilation
- cell cycle arrest
- intensive care unit
- acute kidney injury
- septic shock
- lps induced
- epithelial mesenchymal transition
- cell death
- lipopolysaccharide induced
- endothelial cells
- reactive oxygen species
- oxidative stress