Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome.

Belinda Gray Alban-Elouen Baruteau Albert A Antolin Alan M Pittman Giselle Sarganas Mariam Molokhia Marieke T Blom Rachel Bastiaenen Abdenasser Bardai Silvia Giuliana Priori Carlo NapolitanoPeter E WeekeSaad A ShakirWilhelm Haverkamp Jordi Mestres Bo Gregers Winkel Adam A Witney Irina Chis-SterAjanthah SangaralingamAlan John Camm Jacob Tfelt Hansen Dan M Roden Hanno L TanEdeltraut GarbeMiriam C J M Sturkenboom Elijah R Behr

Published in: Circulation. Genomic and precision medicine (2022)

Rare susceptibility variants in CYP genes are emerging as potentially important pharmacogenomic risk markers for aLQTS and could form part of personalized medicine approaches in the future.

Keyphrases

genome wide
drug induced
copy number
bioinformatics analysis
genome wide identification
dna methylation
current status
case report
emergency department
adverse drug
clinical decision support