An HGF-dependent positive feedback loop between bladder cancer cells and fibroblasts mediates lymphangiogenesis and lymphatic metastasis.

Yuting LiHanhao ZhengYuming LuoYan LinMingjie AnYao KongYue ZhaoYina YinLe AiJian HuangChanghao Chen

Published in: Cancer communications (London, England) (2023)

Our study uncovers a precise mechanism that LINC00665 sustains BCa LN metastasis by inducing a RAB27B-HGF-c-Myc positive feedback loop between BCa cells and fibroblasts, suggesting that LINC00665 could be a promising therapeutic target for patients with LN metastatic BCa.

Keyphrases

long non coding rna
long noncoding rna
induced apoptosis
cell proliferation
extracellular matrix
small cell lung cancer
transcription factor
squamous cell carcinoma
cell cycle arrest
lymph node
spinal cord injury
oxidative stress
endoplasmic reticulum stress
signaling pathway