Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma.

Nagendra K ChaturvediSidharth MahapatraVarun KesherwaniMatthew J KlingMamta ShuklaSutapa RayRanjana KanchanNaveenkumar PerumalTimothy R McGuireJ Graham SharpShantaram S JoshiDon W Coulter

Published in: BMC cancer (2019)

Our results reveal the regulation of MYC oncoprotein by PRMT5 and suggest that targeting PRMT5 could be a potential therapeutic strategy for MYC-driven medulloblastoma.

Keyphrases

transcription factor
nitric oxide
amino acid
genome wide
protein protein
gene expression
binding protein
drug delivery
small molecule