Impact of Nodal Metastases in HPV-Negative Oropharyngeal Cancer.
Clifford M ChangMichelle M ChenEmily Light BellileLaura S RozekThomas E CareyMatthew E SpectorGregory T WolfJeremy M G TaylorSteven Bennett ChinnPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2022)
We demonstrate, for the first time that when nodal staging is deemphasized as a part of overall staging, we see improved concordance and risk stratification for HPV-negative OPSCC. The exact mechanism of this differential impact remains unknown but offers a novel area of study.