Blood-Nanoparticle Interactions Create a Brain Delivery Superhighway for Doxorubicin.
Zhuoxuan LiTatyana KovshovaJulia MalinovskayaJulian KnollSaeed ShanehsazzadehNadezhda OsipovaAnastasia ChernyshevaPavel MelnikovSvetlana GelperinaMatthias Gerhard WackerPublished in: International journal of nanomedicine (2024)
The nonspecific binding to blood cells facilitated and intensified interactions of surfactant-coated PBCA nanoparticles with the vascular endothelium, leading to enhanced transcytosis. Consequently, the significant increase in circulation time in the bloodstream, coupled with improved receptor interactions, contributes to this remarkable uptake of doxorubicin into the brain.
Keyphrases
- resting state
- white matter
- induced apoptosis
- drug delivery
- blood brain barrier
- cancer therapy
- nitric oxide
- functional connectivity
- cerebral ischemia
- cell cycle arrest
- signaling pathway
- multiple sclerosis
- escherichia coli
- gram negative
- cell death
- endoplasmic reticulum stress
- cell proliferation
- subarachnoid hemorrhage
- multidrug resistant