Histopathological correlation of diffusion basis spectrum imaging metrics of a biopsy-proven inflammatory demyelinating brain lesion: A brief report.
Afsaneh ShiraniPeng SunRobert E SchmidtKathryn TrinkausRobert T NaismithSheng-Kwei SongAnne H CrossPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2018)
Diffusion basis spectrum imaging (DBSI) models diffusion-weighted magnetic resonance imaging (MRI) signals as a combination of discrete anisotropic diffusion tensors and a spectrum of isotropic diffusion tensors. Here, we report the histopathological correlates of DBSI in the biopsied brain tissue of a patient with an inflammatory demyelinating lesion typical of multiple sclerosis (MS). Increased radial diffusivity (marker of demyelination), decreased fiber fraction (apparent axonal density), elevated nonrestricted isotropic fraction (marker of vasogenic edema), but unchanged axial diffusivity (marker of integrity of residual axons) seen in the lesion appeared consistent with histopathological findings of inflammatory demyelination with relative axonal sparing. Our report supports the application of DBSI as a biomarker in human studies of MS.
Keyphrases
- multiple sclerosis
- contrast enhanced
- magnetic resonance imaging
- diffusion weighted
- white matter
- high resolution
- oxidative stress
- mass spectrometry
- diffusion weighted imaging
- spinal cord injury
- ms ms
- resting state
- computed tomography
- endothelial cells
- functional connectivity
- cerebral ischemia
- subarachnoid hemorrhage
- fluorescence imaging
- optic nerve
- optical coherence tomography