Tumorigenic transformation of human prostatic epithelial cell line RWPE-1 by growth hormone-releasing hormone (GHRH).

Laura Muñoz-Moreno M José CarmenaJuan C PrietoAndrew V Schally Ana M Bajo

Published in: The Prostate (2022)

Thus, GHRH appears to act as a cytokine in the transformation of RWPE-1 cells by mechanisms that likely involve epithelial-mesenchymal transition, thus reinforcing the role of GHRH in tumorigenesis of prostate.

Keyphrases

growth hormone
epithelial mesenchymal transition
benign prostatic hyperplasia
induced apoptosis
endothelial cells
prostate cancer
cell cycle arrest
signaling pathway
induced pluripotent stem cells
pi k akt