Genome-wide association studies of fertility and calving traits in Brown Swiss cattle using imputed whole-genome sequences.

Mirjam FrischknechtBeat BapstFranz R SeefriedHeidi Signer-HaslerDorian GarrickChristian Strickernull nullRuedi FriesIngolf RussJohann SölknerAnna BieberMaria G StrillacciBirgit Gredler-GrandlChristine Flury

Published in: BMC genomics (2017)

The detection of QTL and their causative variants remains challenging. Combining comprehensive phenotypic data with imputed whole genome sequences seems promising. We present a QTL on BTA17 for female fertility in dairy cattle with two significantly associated non-synonymous SNPs, along with five additional QTL for fertility traits and calving traits. For all of these we fine mapped the regions and suggest candidate genes and candidate variants.

Keyphrases

genome wide
genome wide association
copy number
high density
childhood cancer
dna methylation
air pollution
electronic health record
big data
young adults
machine learning
label free
real time pcr
genetic diversity
sensitive detection