Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.
Sarah BergerCengiz GoekeriShishir K GuptaJulio VeraKristina DietertUlrike BehrendtJasmin LienauSandra-Maria WienholdAchim D GruberNorbert SuttorpMartin WitzenrathGeraldine NouaillesPublished in: Critical care (London, England) (2018)
Our data show that only early antibiotic therapy, administered prior to breakdown of the alveolar-capillary barrier and systemic inflammation, led to restored fitness and rescued mice from fatal streptococcal pneumonia. The findings highlight the importance of identifying CAP patients prior to lung barrier failure and systemic inflammation and of handling CAP as a medical emergency.
Keyphrases
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