Acute Hepatitis due to Primary Human Immunodeficiency Virus Infection.
Eric I ElliottDaisy SmithJonathan LipscombBubu A BaniniLindsay MeurerThomas H VanderfordJeffrey A JohnsonDhanpat JainAmit AchhraPublished in: Open forum infectious diseases (2024)
The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflammation consistent with acute hepatitis, high levels of HIV proviral DNA were detected within liver tissue, and immunofluorescence showed HIV p24 antigen within immune and parenchymal cells including hepatocytes. We review the literature pertaining to HIV infection of cell compartments within the liver and discuss the implications for HIV-associated acute liver disease.
Keyphrases
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- liver failure
- hiv positive
- hepatitis c virus
- hiv aids
- drug induced
- respiratory failure
- liver injury
- aortic dissection
- rare case
- hiv testing
- systematic review
- cell proliferation
- oxidative stress
- single cell
- induced apoptosis
- men who have sex with men
- south africa
- cell therapy
- endoplasmic reticulum stress
- single molecule
- bone marrow
- circulating tumor
- nucleic acid