Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation.

Ruben S A GoedegebuureEsther A KleibeukerFrancesca M BuffaKitty C M CastricumSyed HaiderIris A SchulkensLuuk Ten KroodeJaap van den BergMaarten A J M JacobsAnne-Marie van BerkelNicole C T van GriekenSarah DerksBen J SlotmanHenk M W VerheulAdrian L HarrisVictor L Thijssen

Published in: Journal of experimental & clinical cancer research : CR (2021)

Collectively, the presented data show that clinically applied fractionated low-dose irradiation can induce a delayed type I interferon response that occurs independently of interferon expression or STING signaling. These findings have implications for current efforts that aim to target the type I interferon response for cancer treatment.

Keyphrases

dendritic cells
low dose
high dose
big data
small cell lung cancer
radiation induced
immune response
genome wide
transcription factor
binding protein