A proteomic perspective on the resistance response of Klebsiella pneumoniae to antimicrobial peptide PaDBS1R1.

Osmel FleitasWagner FontesCamila M De SouzaMylena C Da CostaMarlon H CardosoMariana S CastroMarcelo V SousaCarlos A O RicartMarcelo H S RamadaHarry M DuqueWilliam F PortoOsmar N SilvaOctávio Luiz Franco

Published in: The Journal of antimicrobial chemotherapy (2023)

Based on experimental evolution and a label-free quantitative shotgun proteomic approach, we showed that K. pneumoniae developed resistance against PaDBS1R1, whereas PhoPQ-guided LPS modifications and CpxRA-dependent folding machinery appear to be relevant resistance mechanisms against PaDBS1R1.

Keyphrases

label free
klebsiella pneumoniae
escherichia coli
multidrug resistant
high resolution
single molecule
mass spectrometry
anti inflammatory