Genome-wide interaction study of early-life smoking exposure on time-to-asthma onset in childhood.
Pierre-Emmanuel SugierChloé SarnowskiRaquel GranellCatherine LapriseMarkus J EgePatricia Margaritte-JeanninMarie-Hélène DizierCosetta MinelliMiriam F MoffattMark LathropWilliam O C M CooksonA John HendersonErika von MutiusManolis KogevinasFlorence DemenaisEmmanuelle BouzigonPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)
We identified novel candidate genes interacting with ELTS exposure on time-to-asthma onset in childhood. These genes have plausible biological relevance related to tobacco smoke exposure. Further epigenetic and functional studies are needed to confirm these findings and to shed light on the underlying mechanisms.